The Orphaned Pharmacopoeia LogoOff-patent medicine · new uses

Medicines we already have,
for diseases nobody
tried them on

Every generic approved in the United States, with what it is made of, where in the body it reaches, what else its biology points at, and whether anyone has run the trial.

1,208
Generic medicines
off-patent, human safety already established
550
New uses checked
one medicine paired with one condition it is not approved for
312
Never tested in people
no registered trial anywhere for that pairing
28
Stopped after Phase 2
safety and dosing already established, then abandoned
WHAT IT COULD TREAT
WHAT IT'S BUILT FROM
HOW FAR ANYONE HAS TAKEN IT
Showing 140 of 1,208 generic medicines
Amitriptyline Hydrochloride — full profile
Amitriptyline Hydrochloride
Non-selective monoamine reuptake inhibitors · could also reach obsessive-compulsive disorder
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
36.6M
people
55
abandoned
Amoxapine — full profile
Amoxapine
Non-selective monoamine reuptake inhibitors · could also reach obsessive-compulsive disorder
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
36.6M
people
9
abandoned
Aripiprazole — full profile
Aripiprazole
Other antipsychotics · could also reach major depressive disorder
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
35.3M
people
32
abandoned
Asenapine Maleate — full profile
Asenapine Maleate
Diazepines, oxazepines, thiazepines and oxepines · could also reach major depressive disorder
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
34.2M
people
0
abandoned
Baricitinib — full profile
Baricitinib
Janus-associated kinase (JAK) inhibitors · could also reach acquired polycythemia vera
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
29.6M
people
0
abandoned
Bosutinib Monohydrate — full profile
Bosutinib Monohydrate1 WRONG-WAY
BCR-ABL tyrosine kinase inhibitors · could also reach chronic myelogenous leukemia, BCR-ABL1 positive
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
28.1M
people
0
abandoned
Brexpiprazole — full profile
Brexpiprazole
Other antipsychotics · could also reach major depressive disorder
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
35.3M
people
0
abandoned
Bupropion Hydrochloride — full profile
Bupropion Hydrochloride
Centrally acting antiobesity products · could also reach Infantile dystonia-parkinsonism
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
29.3M
people
25
abandoned
Butenafine Hydrochloride — full profile
Butenafine Hydrochloride
Other antifungals for topical use · could also reach autosomal recessive distal spinal muscular atrophy 2
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
51.5M
people
10
abandoned
Chloroquine Phosphate — full profile
Chloroquine Phosphate
Biguanides · could also reach Romano-Ward syndrome
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
46.5M
people
27
abandoned
Ciprofloxacin — full profile
Ciprofloxacin
Fluoroquinolones · could also reach neoplasm
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
18.0M
people
35
abandoned
Ciprofloxacin Hydrochloride — full profile
Ciprofloxacin Hydrochloride
Fluoroquinolones · could also reach neoplasm
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
18.0M
people
55
abandoned
Clofarabine — full profile
Clofarabine
Purine analogues · could also reach non-small cell lung carcinoma
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
21.7M
people
51
abandoned
Clomipramine Hydrochloride — full profile
Clomipramine Hydrochloride
Non-selective monoamine reuptake inhibitors · could also reach obsessive-compulsive disorder
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
36.6M
people
55
abandoned
Clotrimazole — full profile
Clotrimazole
Antiinfectives and antiseptics for local oral treatment · could also reach congenital adrenal hyperplasia due to 17-alpha-hydro
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
17.4M
people
40
abandoned
Clozapine — full profile
Clozapine
Diazepines, oxazepines, thiazepines and oxepines · could also reach major depressive disorder
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
34.2M
people
0
abandoned
Colchicine — full profile
Colchicine
Preparations with no effect on uric acid metabolism · could also reach multiple benign circumferential skin creases on limb
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
31.7M
people
17
abandoned
Cycloserine — full profile
Cycloserine
Antibiotics · could also reach neurodevelopmental disorder with or without hyperkin
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
24.4M
people
0
abandoned
Dasatinib — full profile
Dasatinib3 WRONG-WAY
BCR-ABL tyrosine kinase inhibitors · could also reach gastrointestinal stromal tumor
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
44.7M
people
18
abandoned
Desvenlafaxine Succinate — full profile
Desvenlafaxine Succinate
Other antidepressants · could also reach obsessive-compulsive disorder
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
36.6M
people
21
abandoned
Diazepam — full profile
Diazepam
Benzodiazepine derivatives · could also reach developmental and epileptic encephalopathy, 43
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
27.1M
people
25
abandoned
Dipyridamole — full profile
Dipyridamole3 WRONG-WAY
Platelet aggregation inhibitors excl. heparin · could also reach infantile-onset generalized dyskinesia with orofacia
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
24.5M
people
63
abandoned
Docetaxel — full profile
Docetaxel
Taxanes · could also reach multiple benign circumferential skin creases on limb
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
16.7M
people
32
abandoned
Doxepin Hydrochloride — full profile
Doxepin Hydrochloride
Other antipruritics · could also reach attention deficit-hyperactivity disorder
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
34.8M
people
25
abandoned
Doxorubicin Hydrochloride — full profile
Doxorubicin Hydrochloride
Anthracyclines and related substances · could also reach neoplasm
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
18.0M
people
70
abandoned
Droperidol — full profile
Droperidol
Butyrophenone derivatives · could also reach major depressive disorder
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
34.2M
people
9
abandoned
Duloxetine Hydrochloride — full profile
Duloxetine Hydrochloride
Other antidepressants · could also reach obsessive-compulsive disorder
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
36.6M
people
25
abandoned
Econazole Nitrate — full profile
Econazole Nitrate
Imidazole and triazole derivatives · could also reach ghosal hematodiaphyseal dysplasia
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
40.0M
people
0
abandoned
Epinephrine — full profile
Epinephrine
Other agents for local oral treatment · could also reach hypertensive disorder
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
30.3M
people
33
abandoned
Eribulin Mesylate — full profile
Eribulin Mesylate
Other antineoplastic agents · could also reach multiple benign circumferential skin creases on limb
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
16.7M
people
25
abandoned
Erlotinib Hydrochloride — full profile
Erlotinib Hydrochloride
Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors · could also reach non-small cell lung carcinoma
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
23.4M
people
48
abandoned
Erythromycin — full profile
Erythromycin
Antiinfectives for treatment of acne · could also reach Romano-Ward syndrome
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
22.0M
people
70
abandoned
Ethambutol Hydrochloride — full profile
Ethambutol Hydrochloride
Other drugs for treatment of tuberculosis · could also reach major depressive disorder
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
35.2M
people
9
abandoned
Etoposide — full profile
Etoposide
Podophyllotoxin derivatives · could also reach neoplasm
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
18.0M
people
49
abandoned
Flumazenil — full profile
Flumazenil
Antidotes · could also reach childhood absence epilepsy
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
26.6M
people
44
abandoned
Fulvestrant — full profile
Fulvestrant
Anti-estrogens · could also reach breast cancer
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
20.3M
people
25
abandoned
Gefitinib — full profile
Gefitinib
Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors · could also reach non-small cell lung carcinoma
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
23.4M
people
19
abandoned
Imatinib Mesylate — full profile
Imatinib Mesylate2 WRONG-WAY
BCR-ABL tyrosine kinase inhibitors · could also reach gastrointestinal stromal tumor
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
31.1M
people
25
abandoned
Imipramine Hydrochloride — full profile
Imipramine Hydrochloride
Non-selective monoamine reuptake inhibitors · could also reach obsessive-compulsive disorder
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
36.6M
people
34
abandoned
Imipramine Pamoate — full profile
Imipramine Pamoate
Non-selective monoamine reuptake inhibitors · could also reach obsessive-compulsive disorder
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
5
new uses
36.6M
people
9
abandoned

All of these medicines carry manufacturers, routes and patent status, and each one has its own page with the full profile — composition, reach, binding targets, candidate new uses and trial status. 735 also carry measured binding targets, and 110 have had possible new uses checked against trial records. The remainder are unanalysed, not ruled out. Brand-name medicines with no generic are searchable but kept out of the list, since a company still owns them. Possible uses are drawn from published target–condition links and counted only where the drug engages that target at a dose people already tolerate. Direction checks read variant-consequence annotations, which mislabel some gain-of-function variants, so treat them as a screen rather than a verdict. Nothing here is medical advice.