The Orphaned Pharmacopoeia LogoOff-patent medicine · new uses

Medicines we already have,
for diseases nobody
tried them on

Every generic approved in the United States, with what it is made of, where in the body it reaches, what else its biology points at, and whether anyone has run the trial.

1,208
Generic medicines
off-patent, human safety already established
550
New uses checked
one medicine paired with one condition it is not approved for
312
Never tested in people
no registered trial anywhere for that pairing
28
Stopped after Phase 2
safety and dosing already established, then abandoned
WHAT IT COULD TREAT
WHAT IT'S BUILT FROM
HOW FAR ANYONE HAS TAKEN IT
Showing 12011208 of 1,208 generic medicines
Zidovudine — full profile
Zidovudine
Nucleoside and nucleotide reverse transcriptase inhibitors
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
28.7M
people
42
abandoned
Zileuton — full profile
Zileuton
Class not recorded
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
5.3M
people
35
abandoned
Zinc Chloride — full profile
Zinc Chloride
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Zinc Sulfate — full profile
Zinc Sulfate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Zoledronic Acid — full profile
Zoledronic Acid
Bisphosphonates
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
4.0M
people
25
abandoned
Zolmitriptan — full profile
Zolmitriptan
Selective serotonin (5HT1) agonists
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
5.2M
people
55
abandoned
Zolpidem Tartrate — full profile
Zolpidem Tartrate
Benzodiazepine related drugs
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
22.5M
people
25
abandoned
Zonisamide — full profile
Zonisamide
Other antiepileptics
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
6
abandoned

All of these medicines carry manufacturers, routes and patent status, and each one has its own page with the full profile — composition, reach, binding targets, candidate new uses and trial status. 735 also carry measured binding targets, and 110 have had possible new uses checked against trial records. The remainder are unanalysed, not ruled out. Brand-name medicines with no generic are searchable but kept out of the list, since a company still owns them. Possible uses are drawn from published target–condition links and counted only where the drug engages that target at a dose people already tolerate. Direction checks read variant-consequence annotations, which mislabel some gain-of-function variants, so treat them as a screen rather than a verdict. Nothing here is medical advice.