The Orphaned Pharmacopoeia LogoOff-patent medicine · new uses

Medicines we already have,
for diseases nobody
tried them on

Every generic approved in the United States, with what it is made of, where in the body it reaches, what else its biology points at, and whether anyone has run the trial.

1,208
Generic medicines
off-patent, human safety already established
550
New uses checked
one medicine paired with one condition it is not approved for
312
Never tested in people
no registered trial anywhere for that pairing
28
Stopped after Phase 2
safety and dosing already established, then abandoned
WHAT IT COULD TREAT
WHAT IT'S BUILT FROM
HOW FAR ANYONE HAS TAKEN IT
Showing 801840 of 1,208 generic medicines
Manganese Chloride — full profile
Manganese Chloride
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Mannitol — full profile
Mannitol
Osmotically acting laxatives
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Maraviroc — full profile
Maraviroc
Other antivirals
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
2.1M
people
27
abandoned
Mecamylamine Hydrochloride — full profile
Mecamylamine Hydrochloride
Secondary and tertiary amines
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
3.6M
people
0
abandoned
Meclizine Hydrochloride — full profile
Meclizine Hydrochloride
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Meclofenamate Sodium — full profile
Meclofenamate Sodium
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Medroxyprogesterone Acetate — full profile
Medroxyprogesterone Acetate
Progestogens and estrogens, fixed combinations
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
11.5M
people
47
abandoned
Mefenamic Acid — full profile
Mefenamic Acid
Fenamates
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
15.0M
people
19
abandoned
Megestrol Acetate — full profile
Megestrol Acetate
Progestogens
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
34
abandoned
Meloxicam — full profile
Meloxicam
Amides
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
15.0M
people
25
abandoned
Melphalan Hydrochloride — full profile
Melphalan Hydrochloride
Nitrogen mustard analogues
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
17
abandoned
Memantine Hydrochloride — full profile
Memantine Hydrochloride
Anticholinesterases
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
15.4M
people
63
abandoned
Meperidine Hydrochloride — full profile
Meperidine Hydrochloride
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Mepivacaine Hydrochloride — full profile
Mepivacaine Hydrochloride
Amides
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
9
abandoned
Meprobamate — full profile
Meprobamate
Carbamates
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
9
abandoned
Mercaptopurine — full profile
Mercaptopurine
Purine analogues
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
9
abandoned
Meropenem — full profile
Meropenem
Carbapenems
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
56
abandoned
Mesalamine — full profile
Mesalamine
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Mesna — full profile
Mesna
Mucolytics
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
47
abandoned
Metaproterenol Sulfate — full profile
Metaproterenol Sulfate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Metaraminol Bitartrate — full profile
Metaraminol Bitartrate
Adrenergic and dopaminergic agents
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Metaxalone — full profile
Metaxalone
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
1
abandoned
Metformin Hydrochloride — full profile
Metformin Hydrochloride
Combinations of oral blood glucose lowering drugs
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
70
abandoned
Metformin Hydrochloride; Pioglitazone Hydrochloride — full profile
Metformin Hydrochloride; Pioglitazone Hydrochloride
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Metformin Hydrochloride; Saxagliptin Hydrochloride — full profile
Metformin Hydrochloride; Saxagliptin Hydrochloride
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Metformin Hydrochloride; Sitagliptin Phosphate — full profile
Metformin Hydrochloride; Sitagliptin Phosphate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Methadone Hydrochloride — full profile
Methadone Hydrochloride
Drugs used in opioid dependence
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
21.6M
people
63
abandoned
Methamphetamine Hydrochloride — full profile
Methamphetamine Hydrochloride
Centrally acting sympathomimetics
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
18.3M
people
9
abandoned
Methazolamide — full profile
Methazolamide
Carbonic anhydrase inhibitors
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
16.7M
people
47
abandoned
Methenamine Hippurate — full profile
Methenamine Hippurate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Methimazole — full profile
Methimazole
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Methocarbamol — full profile
Methocarbamol
Carbamic acid esters
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
4.2M
people
25
abandoned
Methohexital Sodium — full profile
Methohexital Sodium
Barbiturates, plain
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Methoxsalen — full profile
Methoxsalen
Psoralens for topical use
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
10.8M
people
2
abandoned
Methscopolamine Bromide — full profile
Methscopolamine Bromide
Belladonna alkaloids, semisynthetic, quaternary ammonium compounds
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
19.8M
people
19
abandoned
Methsuximide — full profile
Methsuximide
Succinimide derivatives
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Methyldopa — full profile
Methyldopa
Methyldopa
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
2
abandoned
Methylene Blue — full profile
Methylene Blue
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Methylergonovine Maleate — full profile
Methylergonovine Maleate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Methylprednisolone — full profile
Methylprednisolone
Corticosteroids, potent (group III)
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
20.1M
people
39
abandoned

All of these medicines carry manufacturers, routes and patent status, and each one has its own page with the full profile — composition, reach, binding targets, candidate new uses and trial status. 735 also carry measured binding targets, and 110 have had possible new uses checked against trial records. The remainder are unanalysed, not ruled out. Brand-name medicines with no generic are searchable but kept out of the list, since a company still owns them. Possible uses are drawn from published target–condition links and counted only where the drug engages that target at a dose people already tolerate. Direction checks read variant-consequence annotations, which mislabel some gain-of-function variants, so treat them as a screen rather than a verdict. Nothing here is medical advice.