The Orphaned Pharmacopoeia LogoOff-patent medicine · new uses

Medicines we already have,
for diseases nobody
tried them on

Every generic approved in the United States, with what it is made of, where in the body it reaches, what else its biology points at, and whether anyone has run the trial.

1,208
Generic medicines
off-patent, human safety already established
550
New uses checked
one medicine paired with one condition it is not approved for
312
Never tested in people
no registered trial anywhere for that pairing
28
Stopped after Phase 2
safety and dosing already established, then abandoned
WHAT IT COULD TREAT
WHAT IT'S BUILT FROM
HOW FAR ANYONE HAS TAKEN IT
Showing 881920 of 1,208 generic medicines
Naltrexone Hydrochloride — full profile
Naltrexone Hydrochloride
Centrally acting antiobesity products
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
23.3M
people
39
abandoned
Naphazoline Hydrochloride; Pheniramine Maleate — full profile
Naphazoline Hydrochloride; Pheniramine Maleate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Naproxen — full profile
Naproxen
Propionic acid derivatives
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
63
abandoned
Naproxen Sodium — full profile
Naproxen Sodium
Propionic acid derivatives
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
78
abandoned
Naproxen Sodium; Pseudoephedrine Hydrochloride — full profile
Naproxen Sodium; Pseudoephedrine Hydrochloride
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Naproxen Sodium; Sumatriptan Succinate — full profile
Naproxen Sodium; Sumatriptan Succinate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Naratriptan Hydrochloride — full profile
Naratriptan Hydrochloride
Selective serotonin (5HT1) agonists
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
5.2M
people
19
abandoned
Nateglinide — full profile
Nateglinide
Other blood glucose lowering drugs, excl. insulins
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
18.5M
people
39
abandoned
Nebivolol Hydrochloride — full profile
Nebivolol Hydrochloride
Angiotensin II receptor blockers (ARBs), other combinations
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
18.4M
people
55
abandoned
Nebivolol Hydrochloride; Valsartan — full profile
Nebivolol Hydrochloride; Valsartan
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Nelarabine — full profile
Nelarabine
Purine analogues
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
63
abandoned
Neomycin Sulfate — full profile
Neomycin Sulfate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Neomycin Sulfate; Polymyxin B Sulfate — full profile
Neomycin Sulfate; Polymyxin B Sulfate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Neostigmine Methylsulfate — full profile
Neostigmine Methylsulfate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Nevirapine — full profile
Nevirapine
Non-nucleoside reverse transcriptase inhibitors
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
51
abandoned
Niacin — full profile
Niacin
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Nicardipine Hydrochloride — full profile
Nicardipine Hydrochloride
Dihydropyridine derivatives
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
32
abandoned
Nicotine — full profile
Nicotine
Drugs used in nicotine dependence
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
5.6M
people
10
abandoned
Nicotine Polacrilex — full profile
Nicotine Polacrilex
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Nilotinib Hydrochloride — full profile
Nilotinib Hydrochloride
BCR-ABL tyrosine kinase inhibitors
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
15.2M
people
9
abandoned
Nilutamide — full profile
Nilutamide
Anti-androgens
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
19.0M
people
0
abandoned
Nimodipine — full profile
Nimodipine
Dihydropyridine derivatives
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Nintedanib Esylate — full profile
Nintedanib Esylate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Nisoldipine — full profile
Nisoldipine
Dihydropyridine derivatives
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
16.4M
people
2
abandoned
Nitazoxanide — full profile
Nitazoxanide
Other agents against amoebiasis and other protozoal diseases
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
905K
people
19
abandoned
Nitisinone — full profile
Nitisinone
Various alimentary tract and metabolism products
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
914K
people
0
abandoned
Nitric Oxide — full profile
Nitric Oxide
Other respiratory system products
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Nitrofurantoin — full profile
Nitrofurantoin
Nitrofuran derivatives
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
66K
people
56
abandoned
Nitrofurantoin, Macrocrystalline — full profile
Nitrofurantoin, Macrocrystalline
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Nitrofurantoin; Nitrofurantoin, Macrocrystalline — full profile
Nitrofurantoin; Nitrofurantoin, Macrocrystalline
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Nitroglycerin — full profile
Nitroglycerin
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Nizatidine — full profile
Nizatidine
H2-receptor antagonists
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
7.7M
people
34
abandoned
Norethindrone — full profile
Norethindrone
Progestogens and estrogens, fixed combinations
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
11.5M
people
40
abandoned
Norethindrone Acetate — full profile
Norethindrone Acetate
Progestogens and estrogens, fixed combinations
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
11.5M
people
34
abandoned
Nystatin — full profile
Nystatin
Combinations of antibacterials
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
63
abandoned
Nystatin; Triamcinolone Acetonide — full profile
Nystatin; Triamcinolone Acetonide
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Octreotide Acetate — full profile
Octreotide Acetate
Somatostatin and analogues
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
5.5M
people
37
abandoned
Olmesartan Medoxomil — full profile
Olmesartan Medoxomil
Angiotensin II receptor blockers (ARBs), plain
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
13.6M
people
63
abandoned
Olopatadine Hydrochloride — full profile
Olopatadine Hydrochloride
Antiallergic agents, excl. corticosteroids
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
18.3M
people
25
abandoned
Omega-3-Acid Ethyl Esters — full profile
Omega-3-Acid Ethyl Esters
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned

All of these medicines carry manufacturers, routes and patent status, and each one has its own page with the full profile — composition, reach, binding targets, candidate new uses and trial status. 735 also carry measured binding targets, and 110 have had possible new uses checked against trial records. The remainder are unanalysed, not ruled out. Brand-name medicines with no generic are searchable but kept out of the list, since a company still owns them. Possible uses are drawn from published target–condition links and counted only where the drug engages that target at a dose people already tolerate. Direction checks read variant-consequence annotations, which mislabel some gain-of-function variants, so treat them as a screen rather than a verdict. Nothing here is medical advice.