The Orphaned Pharmacopoeia LogoOff-patent medicine · new uses

Medicines we already have,
for diseases nobody
tried them on

Every generic approved in the United States, with what it is made of, where in the body it reaches, what else its biology points at, and whether anyone has run the trial.

1,208
Generic medicines
off-patent, human safety already established
550
New uses checked
one medicine paired with one condition it is not approved for
312
Never tested in people
no registered trial anywhere for that pairing
28
Stopped after Phase 2
safety and dosing already established, then abandoned
WHAT IT COULD TREAT
WHAT IT'S BUILT FROM
HOW FAR ANYONE HAS TAKEN IT
Showing 10011040 of 1,208 generic medicines
Prednisone — full profile
Prednisone
Corticosteroids acting locally
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
20.1M
people
63
abandoned
Pregabalin — full profile
Pregabalin
Gabapentinoids
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
14.3M
people
25
abandoned
Prilocaine Hydrochloride — full profile
Prilocaine Hydrochloride
Amides
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
12.6M
people
0
abandoned
Primidone — full profile
Primidone
Barbiturates and derivatives
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
44
abandoned
Probenecid — full profile
Probenecid
Preparations with no effect on uric acid metabolism
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
229K
people
19
abandoned
Procainamide Hydrochloride — full profile
Procainamide Hydrochloride
Antiarrhythmics, class Ia
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
34
abandoned
Prochlorperazine — full profile
Prochlorperazine
Phenothiazines with piperazine structure
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
31.6M
people
1
abandoned
Prochlorperazine Edisylate — full profile
Prochlorperazine Edisylate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Prochlorperazine Maleate — full profile
Prochlorperazine Maleate
Phenothiazines with piperazine structure
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
31.6M
people
55
abandoned
Progesterone — full profile
Progesterone
Pregnen (4) derivatives
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
11.5M
people
63
abandoned
Promethazine Hydrochloride — full profile
Promethazine Hydrochloride
Antihistamines for topical use
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
18.3M
people
63
abandoned
Proparacaine Hydrochloride — full profile
Proparacaine Hydrochloride
Local anesthetics
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
12.6M
people
31
abandoned
Propofol — full profile
Propofol
Other general anesthetics
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
55
abandoned
Propranolol Hydrochloride — full profile
Propranolol Hydrochloride
Beta blocking agents, non-selective
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
18.4M
people
32
abandoned
Propylthiouracil — full profile
Propylthiouracil
Thiouracils
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
3.1M
people
19
abandoned
Protamine Sulfate — full profile
Protamine Sulfate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Prucalopride Succinate — full profile
Prucalopride Succinate
Other drugs for constipation
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
8.5M
people
17
abandoned
Pseudoephedrine Hydrochloride — full profile
Pseudoephedrine Hydrochloride
Sympathomimetics
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
42
abandoned
Pyrazinamide — full profile
Pyrazinamide
Combinations of drugs for treatment of tuberculosis
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
22.7M
people
19
abandoned
Pyridostigmine Bromide — full profile
Pyridostigmine Bromide
Anticholinesterases
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
10.3M
people
70
abandoned
Pyridoxine Hydrochloride — full profile
Pyridoxine Hydrochloride
Other plain vitamin preparations
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Quinapril Hydrochloride — full profile
Quinapril Hydrochloride
ACE inhibitors, plain
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
16.8M
people
27
abandoned
Rabeprazole Sodium — full profile
Rabeprazole Sodium
Proton pump inhibitors
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
56
abandoned
Raltegravir Potassium — full profile
Raltegravir Potassium
Integrase inhibitors
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
4.1M
people
0
abandoned
Ramelteon — full profile
Ramelteon
Melatonin receptor agonists
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
9.8M
people
55
abandoned
Ramipril — full profile
Ramipril
ACE inhibitors, plain
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
16.8M
people
48
abandoned
Ranitidine Hydrochloride — full profile
Ranitidine Hydrochloride
H2-receptor antagonists
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
7.7M
people
42
abandoned
Ranolazine — full profile
Ranolazine
Other cardiac preparations
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
17.2M
people
63
abandoned
Rasagiline Mesylate — full profile
Rasagiline Mesylate
Monoamine oxidase B inhibitors
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
3.3M
people
17
abandoned
Regadenoson — full profile
Regadenoson
Other cardiac preparations
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
11.2M
people
32
abandoned
Remifentanil Hydrochloride — full profile
Remifentanil Hydrochloride
Opioid anesthetics
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
19
abandoned
Repaglinide — full profile
Repaglinide
Other blood glucose lowering drugs, excl. insulins
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
18.5M
people
27
abandoned
Ribavirin — full profile
Ribavirin
Antivirals for treatment of HCV infections
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
18.6M
people
27
abandoned
Rifabutin — full profile
Rifabutin
Combinations for eradication of Helicobacter pylori
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
16
abandoned
Rifampin — full profile
Rifampin
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Rifapentine — full profile
Rifapentine
Antibiotics
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
2
abandoned
Rifaximin — full profile
Rifaximin
Antibiotics
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Rilpivirine Hydrochloride — full profile
Rilpivirine Hydrochloride
Non-nucleoside reverse transcriptase inhibitors
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
7.1M
people
0
abandoned
Riluzole — full profile
Riluzole
Other nervous system drugs
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Rimantadine Hydrochloride — full profile
Rimantadine Hydrochloride
Cyclic amines
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned

All of these medicines carry manufacturers, routes and patent status, and each one has its own page with the full profile — composition, reach, binding targets, candidate new uses and trial status. 735 also carry measured binding targets, and 110 have had possible new uses checked against trial records. The remainder are unanalysed, not ruled out. Brand-name medicines with no generic are searchable but kept out of the list, since a company still owns them. Possible uses are drawn from published target–condition links and counted only where the drug engages that target at a dose people already tolerate. Direction checks read variant-consequence annotations, which mislabel some gain-of-function variants, so treat them as a screen rather than a verdict. Nothing here is medical advice.