The Orphaned Pharmacopoeia LogoOff-patent medicine · new uses

Medicines we already have,
for diseases nobody
tried them on

Every generic approved in the United States, with what it is made of, where in the body it reaches, what else its biology points at, and whether anyone has run the trial.

1,208
Generic medicines
off-patent, human safety already established
550
New uses checked
one medicine paired with one condition it is not approved for
312
Never tested in people
no registered trial anywhere for that pairing
28
Stopped after Phase 2
safety and dosing already established, then abandoned
WHAT IT COULD TREAT
WHAT IT'S BUILT FROM
HOW FAR ANYONE HAS TAKEN IT
Showing 121160 of 1,208 generic medicines
Acetaminophen; Butalbital; Caffeine; Codeine Phosphate — full profile
Acetaminophen; Butalbital; Caffeine; Codeine Phosphate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Acetaminophen; Codeine Phosphate — full profile
Acetaminophen; Codeine Phosphate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Acetaminophen; Hydrocodone Bitartrate — full profile
Acetaminophen; Hydrocodone Bitartrate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Acetaminophen; Ibuprofen — full profile
Acetaminophen; Ibuprofen
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Acetaminophen; Oxycodone Hydrochloride — full profile
Acetaminophen; Oxycodone Hydrochloride
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Acetaminophen; Tramadol Hydrochloride — full profile
Acetaminophen; Tramadol Hydrochloride
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Acetazolamide — full profile
Acetazolamide
Carbonic anhydrase inhibitors
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
18.2M
people
70
abandoned
Acetazolamide Sodium — full profile
Acetazolamide Sodium
Carbonic anhydrase inhibitors
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
18.2M
people
47
abandoned
Acetic Acid, Glacial — full profile
Acetic Acid, Glacial
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Acetic Acid, Glacial; Hydrocortisone — full profile
Acetic Acid, Glacial; Hydrocortisone
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Acetylcysteine — full profile
Acetylcysteine
Mucolytics
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
25
abandoned
Acitretin — full profile
Acitretin
Retinoids for treatment of psoriasis
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
39
abandoned
Acyclovir — full profile
Acyclovir
Antivirals
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
63
abandoned
Acyclovir Sodium — full profile
Acyclovir Sodium
Antivirals
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
35
abandoned
Adapalene — full profile
Adapalene
Retinoids for topical use in acne
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
11.8M
people
67
abandoned
Adapalene; Benzoyl Peroxide — full profile
Adapalene; Benzoyl Peroxide
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Adefovir Dipivoxil — full profile
Adefovir Dipivoxil
Nucleoside and nucleotide reverse transcriptase inhibitors
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
16
abandoned
Adenosine — full profile
Adenosine
Other cardiac preparations
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
13.0M
people
59
abandoned
Afatinib Dimaleate — full profile
Afatinib Dimaleate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Albendazole — full profile
Albendazole
Benzimidazole derivatives
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
39
abandoned
Albuterol Sulfate — full profile
Albuterol Sulfate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Albuterol Sulfate; Ipratropium Bromide — full profile
Albuterol Sulfate; Ipratropium Bromide
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Alcaftadine — full profile
Alcaftadine
Other antiallergics
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Alclometasone Dipropionate — full profile
Alclometasone Dipropionate
Corticosteroids, moderately potent (group II)
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
9
abandoned
Alendronate Sodium — full profile
Alendronate Sodium
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Alfuzosin Hydrochloride — full profile
Alfuzosin Hydrochloride
Alpha-adrenoreceptor antagonists
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
16.4M
people
35
abandoned
Aliskiren Hemifumarate — full profile
Aliskiren Hemifumarate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Allopurinol — full profile
Allopurinol
Preparations inhibiting uric acid production
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
2.0M
people
55
abandoned
Allopurinol Sodium — full profile
Allopurinol Sodium
Preparations inhibiting uric acid production
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
2.0M
people
9
abandoned
Almotriptan Malate — full profile
Almotriptan Malate
Selective serotonin (5HT1) agonists
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
5.2M
people
19
abandoned
Alosetron Hydrochloride — full profile
Alosetron Hydrochloride
Serotonin receptor antagonists
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
9.4M
people
27
abandoned
Alpha-Tocopherol Acetate; Ascorbic Acid; Biotin; Cholecalciferol; Cyanocobalamin; Dexpanthenol; Folic Acid; Niacinamide; Pyridoxine Hydrochloride; Riboflavin 5'-Phosphate Sodium; Thiamine Hydrochloride; Vitamin A Palmitate; Vitamin K — full profile
Alpha-Tocopherol Acetate; Ascorbic Acid; Biotin; Cholecalciferol; Cyanocobalamin; Dexpanthenol; Folic Acid; Niacinamide; Pyridoxine Hydrochloride; Riboflavin 5'-Phosphate Sodium; Thiamine Hydrochloride; Vitamin A Palmitate; Vitamin K
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Alprazolam — full profile
Alprazolam
Benzodiazepine derivatives
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
22.5M
people
63
abandoned
Alprostadil — full profile
Alprostadil
Prostaglandins
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
3.7M
people
9
abandoned
Alvimopan — full profile
Alvimopan
Peripheral opioid receptor antagonists
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
21.6M
people
19
abandoned
Amantadine Hydrochloride — full profile
Amantadine Hydrochloride
Adamantane derivatives
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
25
abandoned
Ambrisentan — full profile
Ambrisentan
Antihypertensives for pulmonary arterial hypertension
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
15.6M
people
6
abandoned
Amcinonide — full profile
Amcinonide
Corticosteroids, potent (group III)
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
19
abandoned
Amikacin Sulfate — full profile
Amikacin Sulfate
Other antibiotics for topical use
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
24
abandoned
Amiloride Hydrochloride — full profile
Amiloride Hydrochloride
Other potassium-sparing agents
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
8.2M
people
16
abandoned

All of these medicines carry manufacturers, routes and patent status, and each one has its own page with the full profile — composition, reach, binding targets, candidate new uses and trial status. 735 also carry measured binding targets, and 110 have had possible new uses checked against trial records. The remainder are unanalysed, not ruled out. Brand-name medicines with no generic are searchable but kept out of the list, since a company still owns them. Possible uses are drawn from published target–condition links and counted only where the drug engages that target at a dose people already tolerate. Direction checks read variant-consequence annotations, which mislabel some gain-of-function variants, so treat them as a screen rather than a verdict. Nothing here is medical advice.