The Orphaned Pharmacopoeia LogoOff-patent medicine · new uses

Medicines we already have,
for diseases nobody
tried them on

Every generic approved in the United States, with what it is made of, where in the body it reaches, what else its biology points at, and whether anyone has run the trial.

1,208
Generic medicines
off-patent, human safety already established
550
New uses checked
one medicine paired with one condition it is not approved for
312
Never tested in people
no registered trial anywhere for that pairing
28
Stopped after Phase 2
safety and dosing already established, then abandoned
WHAT IT COULD TREAT
WHAT IT'S BUILT FROM
HOW FAR ANYONE HAS TAKEN IT
Showing 281320 of 1,208 generic medicines
Buprenorphine Hydrochloride — full profile
Buprenorphine Hydrochloride
Oripavine derivatives
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
23.3M
people
17
abandoned
Buprenorphine Hydrochloride; Naloxone Hydrochloride — full profile
Buprenorphine Hydrochloride; Naloxone Hydrochloride
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Buspirone Hydrochloride — full profile
Buspirone Hydrochloride
Azaspirodecanedione derivatives
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
17.6M
people
55
abandoned
Busulfan — full profile
Busulfan
Alkyl sulfonates
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
3.5M
people
51
abandoned
Butoconazole Nitrate — full profile
Butoconazole Nitrate
Imidazole derivatives
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Butorphanol Tartrate — full profile
Butorphanol Tartrate
Morphinan derivatives
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
23.3M
people
27
abandoned
Cabazitaxel — full profile
Cabazitaxel
Taxanes
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Cabergoline — full profile
Cabergoline
Prolactine inhibitors
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
29.9M
people
39
abandoned
Caffeine Citrate — full profile
Caffeine Citrate
Tests for gastric secretion
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
13.0M
people
47
abandoned
Caffeine; Ergotamine Tartrate — full profile
Caffeine; Ergotamine Tartrate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Calcipotriene — full profile
Calcipotriene
Other antipsoriatics for topical use
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
16.1M
people
0
abandoned
Calcitonin Salmon — full profile
Calcitonin Salmon
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Calcitriol — full profile
Calcitriol
Vitamin D and analogues
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
16.1M
people
70
abandoned
Calcium Acetate — full profile
Calcium Acetate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Calcium Carbonate; Famotidine; Magnesium Hydroxide — full profile
Calcium Carbonate; Famotidine; Magnesium Hydroxide
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Calcium Chloride — full profile
Calcium Chloride
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Calcium Chloride; Dextrose; Potassium Chloride; Sodium Chloride; Sodium Lactate — full profile
Calcium Chloride; Dextrose; Potassium Chloride; Sodium Chloride; Sodium Lactate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Calcium Chloride; Magnesium Chloride; Potassium Chloride; Sodium Acetate; Sodium Chloride; Sodium Citrate — full profile
Calcium Chloride; Magnesium Chloride; Potassium Chloride; Sodium Acetate; Sodium Chloride; Sodium Citrate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Calcium Chloride; Magnesium Chloride; Potassium Chloride; Sodium Chloride — full profile
Calcium Chloride; Magnesium Chloride; Potassium Chloride; Sodium Chloride
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Calcium Chloride; Potassium Chloride; Sodium Chloride; Sodium Lactate — full profile
Calcium Chloride; Potassium Chloride; Sodium Chloride; Sodium Lactate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Calcium Gluconate — full profile
Calcium Gluconate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Canagliflozin — full profile
Canagliflozin
Sodium-glucose co-transporter 2 (SGLT2) inhibitors
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
12.9M
people
0
abandoned
Candesartan Cilexetil — full profile
Candesartan Cilexetil
Angiotensin II receptor blockers (ARBs), plain
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
13.6M
people
41
abandoned
Candesartan Cilexetil; Hydrochlorothiazide — full profile
Candesartan Cilexetil; Hydrochlorothiazide
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Cangrelor — full profile
Cangrelor
Platelet aggregation inhibitors excl. heparin
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
8.2M
people
0
abandoned
Capecitabine — full profile
Capecitabine
Pyrimidine analogues
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
63
abandoned
Captopril — full profile
Captopril
ACE inhibitors, plain
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
16.8M
people
44
abandoned
Captopril; Hydrochlorothiazide — full profile
Captopril; Hydrochlorothiazide
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Carbamazepine — full profile
Carbamazepine
Carboxamide derivatives
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
63
abandoned
Carbidopa — full profile
Carbidopa
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
41
abandoned
Carbidopa; Entacapone; Levodopa — full profile
Carbidopa; Entacapone; Levodopa
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Carbidopa; Levodopa — full profile
Carbidopa; Levodopa
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Carbinoxamine Maleate — full profile
Carbinoxamine Maleate
Aminoalkyl ethers
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Carboplatin — full profile
Carboplatin
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Carboprost Tromethamine — full profile
Carboprost Tromethamine
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Carfilzomib — full profile
Carfilzomib
Proteasome inhibitors
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
4.3M
people
0
abandoned
Carglumic Acid — full profile
Carglumic Acid
Amino acids and derivatives
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Carisoprodol — full profile
Carisoprodol
Carbamic acid esters
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
55
abandoned
Carmustine — full profile
Carmustine
Nitrosoureas
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
3.3M
people
44
abandoned
Carteolol Hydrochloride — full profile
Carteolol Hydrochloride
Beta blocking agents, non-selective
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
18.4M
people
0
abandoned

All of these medicines carry manufacturers, routes and patent status, and each one has its own page with the full profile — composition, reach, binding targets, candidate new uses and trial status. 735 also carry measured binding targets, and 110 have had possible new uses checked against trial records. The remainder are unanalysed, not ruled out. Brand-name medicines with no generic are searchable but kept out of the list, since a company still owns them. Possible uses are drawn from published target–condition links and counted only where the drug engages that target at a dose people already tolerate. Direction checks read variant-consequence annotations, which mislabel some gain-of-function variants, so treat them as a screen rather than a verdict. Nothing here is medical advice.