The Orphaned Pharmacopoeia LogoOff-patent medicine · new uses

Medicines we already have,
for diseases nobody
tried them on

Every generic approved in the United States, with what it is made of, where in the body it reaches, what else its biology points at, and whether anyone has run the trial.

1,208
Generic medicines
off-patent, human safety already established
550
New uses checked
one medicine paired with one condition it is not approved for
312
Never tested in people
no registered trial anywhere for that pairing
28
Stopped after Phase 2
safety and dosing already established, then abandoned
WHAT IT COULD TREAT
WHAT IT'S BUILT FROM
HOW FAR ANYONE HAS TAKEN IT
Showing 401440 of 1,208 generic medicines
Cupric Chloride — full profile
Cupric Chloride
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
19
abandoned
Cupric Sulfate — full profile
Cupric Sulfate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Cyanocobalamin — full profile
Cyanocobalamin
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Cyclobenzaprine Hydrochloride — full profile
Cyclobenzaprine Hydrochloride
Other centrally acting agents
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
28.1M
people
25
abandoned
Cyclopentolate Hydrochloride — full profile
Cyclopentolate Hydrochloride
Anticholinergics
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
11
abandoned
Cyclopentolate Hydrochloride; Phenylephrine Hydrochloride — full profile
Cyclopentolate Hydrochloride; Phenylephrine Hydrochloride
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Cyclophosphamide — full profile
Cyclophosphamide
Nitrogen mustard analogues
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
25
abandoned
Cyclosporine — full profile
Cyclosporine
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Cyproheptadine Hydrochloride — full profile
Cyproheptadine Hydrochloride
Other antihistamines for systemic use
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
18.3M
people
55
abandoned
Cytarabine — full profile
Cytarabine
Combinations of antineoplastic agents
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
51
abandoned
Dabigatran Etexilate Mesylate — full profile
Dabigatran Etexilate Mesylate
Direct thrombin inhibitors
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
6.8M
people
18
abandoned
Dacarbazine — full profile
Dacarbazine
Other alkylating agents
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
3.5M
people
27
abandoned
Dactinomycin — full profile
Dactinomycin
Actinomycines
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
42
abandoned
Dalbavancin Hydrochloride — full profile
Dalbavancin Hydrochloride
Glycopeptide antibacterials
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
11
abandoned
Dalfampridine — full profile
Dalfampridine
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Danazol — full profile
Danazol
Antigonadotropins and similar agents
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
9
abandoned
Dantrolene Sodium — full profile
Dantrolene Sodium
Dantrolene and derivatives
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
7.3M
people
35
abandoned
Dapagliflozin — full profile
Dapagliflozin
Combinations of oral blood glucose lowering drugs
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
12.9M
people
17
abandoned
Dapagliflozin; Metformin Hydrochloride — full profile
Dapagliflozin; Metformin Hydrochloride
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Dapagliflozin; Saxagliptin Hydrochloride — full profile
Dapagliflozin; Saxagliptin Hydrochloride
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Dapsone — full profile
Dapsone
Other anti-acne preparations for topical use
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
13.3M
people
25
abandoned
Daptomycin — full profile
Daptomycin
Other antibacterials
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
32
abandoned
Darifenacin Hydrobromide — full profile
Darifenacin Hydrobromide
Drugs for urinary frequency and incontinence
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
16.4M
people
47
abandoned
Darunavir — full profile
Darunavir
Antivirals for treatment of HIV infections, combinations
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
25
abandoned
Daunorubicin Hydrochloride — full profile
Daunorubicin Hydrochloride
Combinations of antineoplastic agents
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
35
abandoned
Decitabine — full profile
Decitabine
Pyrimidine analogues
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
7.8M
people
63
abandoned
Deferasirox — full profile
Deferasirox
Iron chelating agents
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
17
abandoned
Deferiprone — full profile
Deferiprone
Iron chelating agents
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
199K
people
0
abandoned
Deferoxamine Mesylate — full profile
Deferoxamine Mesylate
Iron chelating agents
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
11.5M
people
34
abandoned
Deflazacort — full profile
Deflazacort
Glucocorticoids
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
52
abandoned
Dehydrated Alcohol — full profile
Dehydrated Alcohol
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Demeclocycline Hydrochloride — full profile
Demeclocycline Hydrochloride
Tetracycline and derivatives
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
7.3M
people
16
abandoned
Deoxycholic Acid — full profile
Deoxycholic Acid
Other dermatologicals
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Desipramine Hydrochloride — full profile
Desipramine Hydrochloride
Non-selective monoamine reuptake inhibitors
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
24.1M
people
34
abandoned
Desloratadine — full profile
Desloratadine
Other antihistamines for systemic use
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
18.3M
people
44
abandoned
Desloratadine; Pseudoephedrine Sulfate — full profile
Desloratadine; Pseudoephedrine Sulfate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Desmopressin Acetate — full profile
Desmopressin Acetate
Vasopressin and analogues
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
8.1M
people
32
abandoned
Desogestrel; Ethinyl Estradiol — full profile
Desogestrel; Ethinyl Estradiol
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Desonide — full profile
Desonide
Corticosteroids, moderately potent (group II)
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
48
abandoned
Desoximetasone — full profile
Desoximetasone
Corticosteroids, potent (group III)
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
20.1M
people
17
abandoned

All of these medicines carry manufacturers, routes and patent status, and each one has its own page with the full profile — composition, reach, binding targets, candidate new uses and trial status. 735 also carry measured binding targets, and 110 have had possible new uses checked against trial records. The remainder are unanalysed, not ruled out. Brand-name medicines with no generic are searchable but kept out of the list, since a company still owns them. Possible uses are drawn from published target–condition links and counted only where the drug engages that target at a dose people already tolerate. Direction checks read variant-consequence annotations, which mislabel some gain-of-function variants, so treat them as a screen rather than a verdict. Nothing here is medical advice.