The Orphaned Pharmacopoeia LogoOff-patent medicine · new uses

Medicines we already have,
for diseases nobody
tried them on

Every generic approved in the United States, with what it is made of, where in the body it reaches, what else its biology points at, and whether anyone has run the trial.

1,208
Generic medicines
off-patent, human safety already established
550
New uses checked
one medicine paired with one condition it is not approved for
312
Never tested in people
no registered trial anywhere for that pairing
28
Stopped after Phase 2
safety and dosing already established, then abandoned
WHAT IT COULD TREAT
WHAT IT'S BUILT FROM
HOW FAR ANYONE HAS TAKEN IT
Showing 441480 of 1,208 generic medicines
Dexamethasone — full profile
Dexamethasone
Corticosteroids for local oral treatment
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
20.1M
people
17
abandoned
Dexamethasone Sodium Phosphate — full profile
Dexamethasone Sodium Phosphate
Corticosteroids for local oral treatment
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
20.1M
people
52
abandoned
Dexamethasone; Neomycin Sulfate; Polymyxin B Sulfate — full profile
Dexamethasone; Neomycin Sulfate; Polymyxin B Sulfate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Dexamethasone; Tobramycin — full profile
Dexamethasone; Tobramycin
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Dexchlorpheniramine Maleate — full profile
Dexchlorpheniramine Maleate
Substituted alkylamines
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
18.3M
people
0
abandoned
Dexlansoprazole — full profile
Dexlansoprazole
Proton pump inhibitors
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Dexmedetomidine Hydrochloride — full profile
Dexmedetomidine Hydrochloride
Other hypnotics and sedatives
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
19.5M
people
17
abandoned
Dexmethylphenidate Hydrochloride — full profile
Dexmethylphenidate Hydrochloride
Centrally acting sympathomimetics
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
18.3M
people
63
abandoned
Dexrazoxane Hydrochloride — full profile
Dexrazoxane Hydrochloride
Detoxifying agents for antineoplastic treatment
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
35
abandoned
Dextroamphetamine Sulfate — full profile
Dextroamphetamine Sulfate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Dextromethorphan Hydrobromide; Guaifenesin — full profile
Dextromethorphan Hydrobromide; Guaifenesin
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Dextromethorphan Hydrobromide; Promethazine Hydrochloride — full profile
Dextromethorphan Hydrobromide; Promethazine Hydrochloride
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Dextromethorphan Hydrobromide; Quinidine Sulfate — full profile
Dextromethorphan Hydrobromide; Quinidine Sulfate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Dextromethorphan Polistirex — full profile
Dextromethorphan Polistirex
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Dextrose — full profile
Dextrose
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Dextrose; Potassium Chloride — full profile
Dextrose; Potassium Chloride
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Dextrose; Potassium Chloride; Sodium Chloride — full profile
Dextrose; Potassium Chloride; Sodium Chloride
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Dextrose; Sodium Chloride — full profile
Dextrose; Sodium Chloride
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Diatrizoate Meglumine; Diatrizoate Sodium — full profile
Diatrizoate Meglumine; Diatrizoate Sodium
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Diazoxide — full profile
Diazoxide
Thiazide derivatives
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
18.5M
people
9
abandoned
Dichlorphenamide — full profile
Dichlorphenamide
Carbonic anhydrase inhibitors
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
18.2M
people
16
abandoned
Diclofenac Potassium — full profile
Diclofenac Potassium
Other dermatologicals
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
15.4M
people
17
abandoned
Diclofenac Sodium — full profile
Diclofenac Sodium
Other dermatologicals
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
15.4M
people
86
abandoned
Diclofenac Sodium; Misoprostol — full profile
Diclofenac Sodium; Misoprostol
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Dicloxacillin Sodium — full profile
Dicloxacillin Sodium
Beta-lactamase resistant penicillins
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
16
abandoned
Dicyclomine Hydrochloride — full profile
Dicyclomine Hydrochloride
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Diethylpropion Hydrochloride — full profile
Diethylpropion Hydrochloride
Centrally acting antiobesity products
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
16
abandoned
Diflorasone Diacetate — full profile
Diflorasone Diacetate
Corticosteroids, potent (group III)
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
20.1M
people
27
abandoned
Diflunisal — full profile
Diflunisal
Salicylic acid and derivatives
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
15.0M
people
19
abandoned
Difluprednate — full profile
Difluprednate
Corticosteroids, potent (group III)
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
48
abandoned
Digoxin — full profile
Digoxin
Digitalis glycosides
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
9.5M
people
67
abandoned
Dihydroergotamine Mesylate — full profile
Dihydroergotamine Mesylate
Ergot alkaloids
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
5.0M
people
18
abandoned
Diltiazem Hydrochloride — full profile
Diltiazem Hydrochloride
Muscle relaxants
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
16.4M
people
70
abandoned
Dimenhydrinate — full profile
Dimenhydrinate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Dimethyl Fumarate — full profile
Dimethyl Fumarate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
25
abandoned
Dimethyl Sulfoxide — full profile
Dimethyl Sulfoxide
Other urologicals
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Diphenhydramine Citrate; Ibuprofen — full profile
Diphenhydramine Citrate; Ibuprofen
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Diphenhydramine Hydrochloride — full profile
Diphenhydramine Hydrochloride
Propionic acid derivatives
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
18.3M
people
59
abandoned
Diphenhydramine Hydrochloride; Ibuprofen — full profile
Diphenhydramine Hydrochloride; Ibuprofen
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Diphenhydramine Hydrochloride; Naproxen Sodium — full profile
Diphenhydramine Hydrochloride; Naproxen Sodium
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned

All of these medicines carry manufacturers, routes and patent status, and each one has its own page with the full profile — composition, reach, binding targets, candidate new uses and trial status. 735 also carry measured binding targets, and 110 have had possible new uses checked against trial records. The remainder are unanalysed, not ruled out. Brand-name medicines with no generic are searchable but kept out of the list, since a company still owns them. Possible uses are drawn from published target–condition links and counted only where the drug engages that target at a dose people already tolerate. Direction checks read variant-consequence annotations, which mislabel some gain-of-function variants, so treat them as a screen rather than a verdict. Nothing here is medical advice.