The Orphaned Pharmacopoeia LogoOff-patent medicine · new uses

Medicines we already have,
for diseases nobody
tried them on

Every generic approved in the United States, with what it is made of, where in the body it reaches, what else its biology points at, and whether anyone has run the trial.

1,208
Generic medicines
off-patent, human safety already established
550
New uses checked
one medicine paired with one condition it is not approved for
312
Never tested in people
no registered trial anywhere for that pairing
28
Stopped after Phase 2
safety and dosing already established, then abandoned
WHAT IT COULD TREAT
WHAT IT'S BUILT FROM
HOW FAR ANYONE HAS TAKEN IT
Showing 521560 of 1,208 generic medicines
Enalapril Maleate — full profile
Enalapril Maleate
ACE inhibitors, plain
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
16.8M
people
17
abandoned
Enalapril Maleate; Hydrochlorothiazide — full profile
Enalapril Maleate; Hydrochlorothiazide
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Enalaprilat — full profile
Enalaprilat
Class not recorded
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
16.8M
people
19
abandoned
Enoxaparin Sodium — full profile
Enoxaparin Sodium
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Entacapone — full profile
Entacapone
Other dopaminergic agents
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
1.8M
people
44
abandoned
Entecavir — full profile
Entecavir
Nucleoside and nucleotide reverse transcriptase inhibitors
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
56
abandoned
Enzalutamide — full profile
Enzalutamide
Anti-androgens
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
19.0M
people
0
abandoned
Ephedrine Sulfate — full profile
Ephedrine Sulfate
Adrenergic and dopaminergic agents
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
15.5M
people
17
abandoned
Epinastine Hydrochloride — full profile
Epinastine Hydrochloride
Other antihistamines for systemic use
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
18.3M
people
0
abandoned
Epinephrine Bitartrate; Lidocaine Hydrochloride — full profile
Epinephrine Bitartrate; Lidocaine Hydrochloride
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Epinephrine Bitartrate; Prilocaine Hydrochloride — full profile
Epinephrine Bitartrate; Prilocaine Hydrochloride
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Epinephrine; Lidocaine Hydrochloride — full profile
Epinephrine; Lidocaine Hydrochloride
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Epirubicin Hydrochloride — full profile
Epirubicin Hydrochloride
Anthracyclines and related substances
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
3.9M
people
42
abandoned
Eplerenone — full profile
Eplerenone
Aldosterone antagonists
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
12.9M
people
48
abandoned
Epoprostenol Sodium — full profile
Epoprostenol Sodium
Platelet aggregation inhibitors excl. heparin
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
5.7M
people
0
abandoned
Eptifibatide — full profile
Eptifibatide
Platelet aggregation inhibitors excl. heparin
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
5.6M
people
63
abandoned
Ergocalciferol — full profile
Ergocalciferol
Vitamin D and analogues
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
27
abandoned
Ergotamine Tartrate — full profile
Ergotamine Tartrate
Ergot alkaloids
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
5.0M
people
0
abandoned
Ertapenem Sodium — full profile
Ertapenem Sodium
Carbapenems
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
41
abandoned
Erythromycin Ethylsuccinate — full profile
Erythromycin Ethylsuccinate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Erythromycin Lactobionate — full profile
Erythromycin Lactobionate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Escitalopram Oxalate — full profile
Escitalopram Oxalate
Selective serotonin reuptake inhibitors
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
29.1M
people
55
abandoned
Eslicarbazepine Acetate — full profile
Eslicarbazepine Acetate
Carboxamide derivatives
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
14
abandoned
Esmolol Hydrochloride — full profile
Esmolol Hydrochloride
Beta blocking agents, selective
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
14.3M
people
10
abandoned
Esomeprazole Magnesium — full profile
Esomeprazole Magnesium
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Esomeprazole Magnesium; Naproxen — full profile
Esomeprazole Magnesium; Naproxen
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Esomeprazole Sodium — full profile
Esomeprazole Sodium
Proton pump inhibitors
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
27
abandoned
Estazolam — full profile
Estazolam
Benzodiazepine derivatives
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
19
abandoned
Estradiol — full profile
Estradiol
Natural and semisynthetic estrogens, plain
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
17.1M
people
25
abandoned
Estradiol Cypionate — full profile
Estradiol Cypionate
Natural and semisynthetic estrogens, plain
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Estradiol Valerate — full profile
Estradiol Valerate
Natural and semisynthetic estrogens, plain
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
17.1M
people
19
abandoned
Estradiol; Norethindrone Acetate — full profile
Estradiol; Norethindrone Acetate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Estrogens, Conjugated — full profile
Estrogens, Conjugated
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Estropipate — full profile
Estropipate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Eszopiclone — full profile
Eszopiclone
Benzodiazepine related drugs
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
27.0M
people
52
abandoned
Ethacrynate Sodium — full profile
Ethacrynate Sodium
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Ethacrynic Acid — full profile
Ethacrynic Acid
Aryloxyacetic acid derivatives
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
44
abandoned
Ethinyl Estradiol; Ethynodiol Diacetate — full profile
Ethinyl Estradiol; Ethynodiol Diacetate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Ethinyl Estradiol; Etonogestrel — full profile
Ethinyl Estradiol; Etonogestrel
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Ethinyl Estradiol; Levonorgestrel — full profile
Ethinyl Estradiol; Levonorgestrel
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned

All of these medicines carry manufacturers, routes and patent status, and each one has its own page with the full profile — composition, reach, binding targets, candidate new uses and trial status. 735 also carry measured binding targets, and 110 have had possible new uses checked against trial records. The remainder are unanalysed, not ruled out. Brand-name medicines with no generic are searchable but kept out of the list, since a company still owns them. Possible uses are drawn from published target–condition links and counted only where the drug engages that target at a dose people already tolerate. Direction checks read variant-consequence annotations, which mislabel some gain-of-function variants, so treat them as a screen rather than a verdict. Nothing here is medical advice.