The Orphaned Pharmacopoeia LogoOff-patent medicine · new uses

Medicines we already have,
for diseases nobody
tried them on

Every generic approved in the United States, with what it is made of, where in the body it reaches, what else its biology points at, and whether anyone has run the trial.

1,208
Generic medicines
off-patent, human safety already established
550
New uses checked
one medicine paired with one condition it is not approved for
312
Never tested in people
no registered trial anywhere for that pairing
28
Stopped after Phase 2
safety and dosing already established, then abandoned
WHAT IT COULD TREAT
WHAT IT'S BUILT FROM
HOW FAR ANYONE HAS TAKEN IT
Showing 481520 of 1,208 generic medicines
Diroximel Fumarate — full profile
Diroximel Fumarate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Disopyramide Phosphate — full profile
Disopyramide Phosphate
Antiarrhythmics, class Ia
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
16
abandoned
Disulfiram — full profile
Disulfiram
Drugs used in alcohol dependence
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
19
abandoned
Divalproex Sodium — full profile
Divalproex Sodium
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Dobutamine Hydrochloride — full profile
Dobutamine Hydrochloride
Adrenergic and dopaminergic agents
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
18.4M
people
19
abandoned
Docosanol — full profile
Docosanol
Antivirals
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
54
abandoned
Dofetilide — full profile
Dofetilide
Antiarrhythmics, class III
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
7.1M
people
52
abandoned
Donepezil Hydrochloride — full profile
Donepezil Hydrochloride
Anticholinesterases
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
10.3M
people
17
abandoned
Donepezil Hydrochloride; Memantine Hydrochloride — full profile
Donepezil Hydrochloride; Memantine Hydrochloride
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Dopamine Hydrochloride — full profile
Dopamine Hydrochloride
Adrenergic and dopaminergic agents
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
14.3M
people
0
abandoned
Dorzolamide Hydrochloride — full profile
Dorzolamide Hydrochloride
Carbonic anhydrase inhibitors
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
16.2M
people
52
abandoned
Dorzolamide Hydrochloride; Timolol Maleate — full profile
Dorzolamide Hydrochloride; Timolol Maleate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Doxapram Hydrochloride — full profile
Doxapram Hydrochloride
Respiratory stimulants
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Doxazosin Mesylate — full profile
Doxazosin Mesylate
Alpha-adrenoreceptor antagonists
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
16.4M
people
67
abandoned
Doxercalciferol — full profile
Doxercalciferol
Other anti-parathyroid agents
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
47
abandoned
Doxycycline — full profile
Doxycycline
Antiinfectives and antiseptics for local oral treatment
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
16.1M
people
25
abandoned
Doxycycline Hyclate — full profile
Doxycycline Hyclate
Antiinfectives and antiseptics for local oral treatment
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
16.1M
people
40
abandoned
Doxylamine Succinate — full profile
Doxylamine Succinate
Aminoalkyl ethers
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
24
abandoned
Doxylamine Succinate; Pyridoxine Hydrochloride — full profile
Doxylamine Succinate; Pyridoxine Hydrochloride
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Dronabinol — full profile
Dronabinol
Other antiemetics
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
13.6M
people
0
abandoned
Drospirenone; Estradiol — full profile
Drospirenone; Estradiol
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Drospirenone; Ethinyl Estradiol — full profile
Drospirenone; Ethinyl Estradiol
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Drospirenone; Ethinyl Estradiol; Levomefolate Calcium — full profile
Drospirenone; Ethinyl Estradiol; Levomefolate Calcium
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Droxidopa — full profile
Droxidopa
Adrenergic and dopaminergic agents
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
63
abandoned
Dutasteride — full profile
Dutasteride
Alpha-adrenoreceptor antagonists
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
3.7M
people
63
abandoned
Dutasteride; Tamsulosin Hydrochloride — full profile
Dutasteride; Tamsulosin Hydrochloride
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Dyclonine Hydrochloride — full profile
Dyclonine Hydrochloride
Other local anesthetics
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Edaravone — full profile
Edaravone
Other nervous system drugs
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Edetate Calcium Disodium — full profile
Edetate Calcium Disodium
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Efavirenz — full profile
Efavirenz
Antivirals for treatment of HIV infections, combinations
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
27
abandoned
Efavirenz; Emtricitabine; Tenofovir Disoproxil Fumarate — full profile
Efavirenz; Emtricitabine; Tenofovir Disoproxil Fumarate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate — full profile
Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Efinaconazole — full profile
Efinaconazole
Imidazole and triazole derivatives
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Eletriptan Hydrobromide — full profile
Eletriptan Hydrobromide
Selective serotonin (5HT1) agonists
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
5.2M
people
44
abandoned
Eliglustat Tartrate — full profile
Eliglustat Tartrate
Various alimentary tract and metabolism products
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
5.0M
people
0
abandoned
Eltrombopag Olamine — full profile
Eltrombopag Olamine
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Emtricitabine — full profile
Emtricitabine
Antivirals for treatment of HIV infections, combinations
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
16
abandoned
Emtricitabine; Rilpivirine Hydrochloride; Tenofovir Disoproxil Fumarate — full profile
Emtricitabine; Rilpivirine Hydrochloride; Tenofovir Disoproxil Fumarate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Emtricitabine; Tenofovir Alafenamide Fumarate — full profile
Emtricitabine; Tenofovir Alafenamide Fumarate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Emtricitabine; Tenofovir Disoproxil Fumarate — full profile
Emtricitabine; Tenofovir Disoproxil Fumarate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned

All of these medicines carry manufacturers, routes and patent status, and each one has its own page with the full profile — composition, reach, binding targets, candidate new uses and trial status. 735 also carry measured binding targets, and 110 have had possible new uses checked against trial records. The remainder are unanalysed, not ruled out. Brand-name medicines with no generic are searchable but kept out of the list, since a company still owns them. Possible uses are drawn from published target–condition links and counted only where the drug engages that target at a dose people already tolerate. Direction checks read variant-consequence annotations, which mislabel some gain-of-function variants, so treat them as a screen rather than a verdict. Nothing here is medical advice.