The Orphaned Pharmacopoeia LogoOff-patent medicine · new uses

Medicines we already have,
for diseases nobody
tried them on

Every generic approved in the United States, with what it is made of, where in the body it reaches, what else its biology points at, and whether anyone has run the trial.

1,208
Generic medicines
off-patent, human safety already established
550
New uses checked
one medicine paired with one condition it is not approved for
312
Never tested in people
no registered trial anywhere for that pairing
28
Stopped after Phase 2
safety and dosing already established, then abandoned
WHAT IT COULD TREAT
WHAT IT'S BUILT FROM
HOW FAR ANYONE HAS TAKEN IT
Showing 601640 of 1,208 generic medicines
Fludeoxyglucose F-18 — full profile
Fludeoxyglucose F-18
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Fludrocortisone Acetate — full profile
Fludrocortisone Acetate
Mineralocorticoids
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
12.9M
people
27
abandoned
Flunisolide — full profile
Flunisolide
Corticosteroids
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
20.1M
people
11
abandoned
Fluocinolone Acetonide — full profile
Fluocinolone Acetonide
Corticosteroids
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
20.1M
people
17
abandoned
Fluocinolone Acetonide; Neomycin Sulfate — full profile
Fluocinolone Acetonide; Neomycin Sulfate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Fluocinonide — full profile
Fluocinonide
Corticosteroids
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
20.1M
people
55
abandoned
Fluorescein Sodium — full profile
Fluorescein Sodium
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Fluorometholone — full profile
Fluorometholone
Corticosteroids
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
20.1M
people
1
abandoned
Fluorouracil — full profile
Fluorouracil
Pyrimidine analogues
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
63
abandoned
Fluoxetine Hydrochloride — full profile
Fluoxetine Hydrochloride
Selective serotonin reuptake inhibitors
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
29.1M
people
63
abandoned
Fluoxetine Hydrochloride; Olanzapine — full profile
Fluoxetine Hydrochloride; Olanzapine
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Fluphenazine Decanoate — full profile
Fluphenazine Decanoate
Phenothiazines with piperazine structure
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
59
abandoned
Fluphenazine Hydrochloride — full profile
Fluphenazine Hydrochloride
Phenothiazines with piperazine structure
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
29.9M
people
63
abandoned
Flurandrenolide — full profile
Flurandrenolide
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Flurazepam Hydrochloride — full profile
Flurazepam Hydrochloride
Benzodiazepine derivatives
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
22.0M
people
9
abandoned
Flurbiprofen — full profile
Flurbiprofen
Propionic acid derivatives
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
15.4M
people
0
abandoned
Flurbiprofen Sodium — full profile
Flurbiprofen Sodium
Propionic acid derivatives
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
15.4M
people
0
abandoned
Flutamide — full profile
Flutamide
Anti-androgens
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
19.0M
people
0
abandoned
Fluticasone Propionate — full profile
Fluticasone Propionate
Adrenergics in combination with corticosteroids or other drugs, excl. anticholinergics
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
20.1M
people
40
abandoned
Fluticasone Propionate; Salmeterol Xinafoate — full profile
Fluticasone Propionate; Salmeterol Xinafoate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Fluvastatin Sodium — full profile
Fluvastatin Sodium
HMG CoA reductase inhibitors
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
15.8M
people
27
abandoned
Fluvoxamine Maleate — full profile
Fluvoxamine Maleate
Selective serotonin reuptake inhibitors
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
29.1M
people
63
abandoned
Folic Acid — full profile
Folic Acid
Iron in combination with folic acid
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
70
abandoned
Fomepizole — full profile
Fomepizole
Antidotes
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
27
abandoned
Fondaparinux Sodium — full profile
Fondaparinux Sodium
Other antithrombotic agents
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
9.5M
people
27
abandoned
Formoterol Fumarate — full profile
Formoterol Fumarate
Adrenergics in combination with corticosteroids or other drugs, excl. anticholinergics
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
15.5M
people
55
abandoned
Fosamprenavir Calcium — full profile
Fosamprenavir Calcium
Protease inhibitors
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
16
abandoned
Fosaprepitant Dimeglumine — full profile
Fosaprepitant Dimeglumine
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Foscarnet Sodium — full profile
Foscarnet Sodium
Phosphonic acid derivatives
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
47
abandoned
Fosfomycin Tromethamine — full profile
Fosfomycin Tromethamine
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Fosinopril Sodium — full profile
Fosinopril Sodium
ACE inhibitors, plain
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
16.8M
people
41
abandoned
Fosinopril Sodium; Hydrochlorothiazide — full profile
Fosinopril Sodium; Hydrochlorothiazide
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Fosphenytoin Sodium — full profile
Fosphenytoin Sodium
Hydantoin derivatives
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
39
abandoned
Fostamatinib Disodium — full profile
Fostamatinib Disodium
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Frovatriptan Succinate — full profile
Frovatriptan Succinate
Selective serotonin (5HT1) agonists
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
5.2M
people
27
abandoned
Furosemide — full profile
Furosemide
Sulfonamides and potassium in combination
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
9.1M
people
25
abandoned
Gabapentin — full profile
Gabapentin
Gabapentinoids
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
14.3M
people
55
abandoned
Gadobutrol — full profile
Gadobutrol
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Gadoterate Meglumine — full profile
Gadoterate Meglumine
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Gadoteridol — full profile
Gadoteridol
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned

All of these medicines carry manufacturers, routes and patent status, and each one has its own page with the full profile — composition, reach, binding targets, candidate new uses and trial status. 735 also carry measured binding targets, and 110 have had possible new uses checked against trial records. The remainder are unanalysed, not ruled out. Brand-name medicines with no generic are searchable but kept out of the list, since a company still owns them. Possible uses are drawn from published target–condition links and counted only where the drug engages that target at a dose people already tolerate. Direction checks read variant-consequence annotations, which mislabel some gain-of-function variants, so treat them as a screen rather than a verdict. Nothing here is medical advice.