The Orphaned Pharmacopoeia LogoOff-patent medicine · new uses

Medicines we already have,
for diseases nobody
tried them on

Every generic approved in the United States, with what it is made of, where in the body it reaches, what else its biology points at, and whether anyone has run the trial.

1,208
Generic medicines
off-patent, human safety already established
550
New uses checked
one medicine paired with one condition it is not approved for
312
Never tested in people
no registered trial anywhere for that pairing
28
Stopped after Phase 2
safety and dosing already established, then abandoned
WHAT IT COULD TREAT
WHAT IT'S BUILT FROM
HOW FAR ANYONE HAS TAKEN IT
Showing 641680 of 1,208 generic medicines
Galantamine Hydrobromide — full profile
Galantamine Hydrobromide
Anticholinesterases
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
10.3M
people
63
abandoned
Gallium Ga-68 Edotreotide — full profile
Gallium Ga-68 Edotreotide
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Gallium Ga-68 Gozetotide — full profile
Gallium Ga-68 Gozetotide
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Ganciclovir Sodium — full profile
Ganciclovir Sodium
Nucleosides and nucleotides excl. reverse transcriptase inhibitors
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
9.5M
people
41
abandoned
Ganirelix Acetate — full profile
Ganirelix Acetate
Anti-gonadotropin-releasing hormones
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
54
abandoned
Gatifloxacin — full profile
Gatifloxacin
Fluoroquinolones
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
1
abandoned
Gemcitabine Hydrochloride — full profile
Gemcitabine Hydrochloride
Pyrimidine analogues
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
25
abandoned
Gemfibrozil — full profile
Gemfibrozil
Fibrates
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
48
abandoned
Gentamicin Sulfate — full profile
Gentamicin Sulfate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Glatiramer Acetate — full profile
Glatiramer Acetate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Glimepiride — full profile
Glimepiride
Sulfonylureas
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
18.5M
people
56
abandoned
Glimepiride; Pioglitazone Hydrochloride — full profile
Glimepiride; Pioglitazone Hydrochloride
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Glipizide — full profile
Glipizide
Sulfonylureas
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
18.5M
people
70
abandoned
Glipizide; Metformin Hydrochloride — full profile
Glipizide; Metformin Hydrochloride
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Glucagon — full profile
Glucagon
Glycogenolytic hormones
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
4.6M
people
4
abandoned
Glyburide — full profile
Glyburide
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Glyburide; Metformin Hydrochloride — full profile
Glyburide; Metformin Hydrochloride
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Glycerol Phenylbutyrate — full profile
Glycerol Phenylbutyrate
Various alimentary tract and metabolism products
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
13
abandoned
Glycopyrrolate — full profile
Glycopyrrolate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Gramicidin; Neomycin Sulfate; Polymyxin B Sulfate — full profile
Gramicidin; Neomycin Sulfate; Polymyxin B Sulfate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Granisetron Hydrochloride — full profile
Granisetron Hydrochloride
Serotonin (5HT3) antagonists
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
9.4M
people
63
abandoned
Griseofulvin, Microsize — full profile
Griseofulvin, Microsize
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Griseofulvin, Ultramicrosize — full profile
Griseofulvin, Ultramicrosize
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Guaifenesin — full profile
Guaifenesin
Expectorants
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
75
abandoned
Guaifenesin; Pseudoephedrine Hydrochloride — full profile
Guaifenesin; Pseudoephedrine Hydrochloride
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Guanfacine Hydrochloride — full profile
Guanfacine Hydrochloride
Imidazoline receptor agonists
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
19.0M
people
63
abandoned
Halcinonide — full profile
Halcinonide
Corticosteroids, very potent (group IV)
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
20.1M
people
19
abandoned
Halobetasol Propionate — full profile
Halobetasol Propionate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Halobetasol Propionate; Tazarotene — full profile
Halobetasol Propionate; Tazarotene
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Haloperidol — full profile
Haloperidol
Butyrophenone derivatives
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
29.9M
people
55
abandoned
Haloperidol Decanoate — full profile
Haloperidol Decanoate
Butyrophenone derivatives
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
29.9M
people
67
abandoned
Haloperidol Lactate — full profile
Haloperidol Lactate
Butyrophenone derivatives
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
29.9M
people
51
abandoned
Heparin Sodium — full profile
Heparin Sodium
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Homatropine Methylbromide; Hydrocodone Bitartrate — full profile
Homatropine Methylbromide; Hydrocodone Bitartrate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Hydralazine Hydrochloride — full profile
Hydralazine Hydrochloride
Hydrazinophthalazine derivatives
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
63
abandoned
Hydralazine Hydrochloride; Isosorbide Dinitrate — full profile
Hydralazine Hydrochloride; Isosorbide Dinitrate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Hydrochlorothiazide — full profile
Hydrochlorothiazide
Renin-inhibitors
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
8.8M
people
25
abandoned
Hydrochlorothiazide; Irbesartan — full profile
Hydrochlorothiazide; Irbesartan
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Hydrochlorothiazide; Lisinopril — full profile
Hydrochlorothiazide; Lisinopril
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Hydrochlorothiazide; Losartan Potassium — full profile
Hydrochlorothiazide; Losartan Potassium
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned

All of these medicines carry manufacturers, routes and patent status, and each one has its own page with the full profile — composition, reach, binding targets, candidate new uses and trial status. 735 also carry measured binding targets, and 110 have had possible new uses checked against trial records. The remainder are unanalysed, not ruled out. Brand-name medicines with no generic are searchable but kept out of the list, since a company still owns them. Possible uses are drawn from published target–condition links and counted only where the drug engages that target at a dose people already tolerate. Direction checks read variant-consequence annotations, which mislabel some gain-of-function variants, so treat them as a screen rather than a verdict. Nothing here is medical advice.