The Orphaned Pharmacopoeia LogoOff-patent medicine · new uses

Medicines we already have,
for diseases nobody
tried them on

Every generic approved in the United States, with what it is made of, where in the body it reaches, what else its biology points at, and whether anyone has run the trial.

1,208
Generic medicines
off-patent, human safety already established
550
New uses checked
one medicine paired with one condition it is not approved for
312
Never tested in people
no registered trial anywhere for that pairing
28
Stopped after Phase 2
safety and dosing already established, then abandoned
WHAT IT COULD TREAT
WHAT IT'S BUILT FROM
HOW FAR ANYONE HAS TAKEN IT
Showing 11211160 of 1,208 generic medicines
Tenofovir Alafenamide Fumarate — full profile
Tenofovir Alafenamide Fumarate
Nucleoside and nucleotide reverse transcriptase inhibitors
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Tenofovir Disoproxil Fumarate — full profile
Tenofovir Disoproxil Fumarate
Antivirals for treatment of HIV infections, combinations
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
63
abandoned
Terazosin Hydrochloride — full profile
Terazosin Hydrochloride
Alpha-adrenoreceptor antagonists
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
16.4M
people
34
abandoned
Terbutaline Sulfate — full profile
Terbutaline Sulfate
Selective beta-2-adrenoreceptor agonists
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
15.5M
people
47
abandoned
Teriflunomide — full profile
Teriflunomide
Dihydroorotate dehydrogenase (DHODH) inhibitors
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
2.4M
people
17
abandoned
Teriparatide — full profile
Teriparatide
Parathyroid hormones and analogues
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
2.6M
people
27
abandoned
Testosterone — full profile
Testosterone
3-oxoandrosten (4) derivatives
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
19.0M
people
10
abandoned
Testosterone Cypionate — full profile
Testosterone Cypionate
3-oxoandrosten (4) derivatives
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
14
abandoned
Testosterone Enanthate — full profile
Testosterone Enanthate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Tetrabenazine — full profile
Tetrabenazine
Other nervous system drugs
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
10.9M
people
48
abandoned
Tetracycline Hydrochloride — full profile
Tetracycline Hydrochloride
Combinations for eradication of Helicobacter pylori
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
47
abandoned
Tetrahydrozoline Hydrochloride — full profile
Tetrahydrozoline Hydrochloride
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Thalidomide — full profile
Thalidomide
Other immunosuppressants
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
6.7M
people
0
abandoned
Theophylline — full profile
Theophylline
Xanthines
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
13.0M
people
63
abandoned
Thiamine Hydrochloride — full profile
Thiamine Hydrochloride
Vitamin B1, plain
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
3.4M
people
55
abandoned
Thioridazine Hydrochloride — full profile
Thioridazine Hydrochloride
Phenothiazines with piperidine structure
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
29.9M
people
0
abandoned
Thiotepa — full profile
Thiotepa
Ethylene imines
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
10
abandoned
Thiothixene — full profile
Thiothixene
Thioxanthene derivatives
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
29.9M
people
19
abandoned
Tiagabine Hydrochloride — full profile
Tiagabine Hydrochloride
Fatty acid derivatives
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
2.0M
people
0
abandoned
Ticagrelor — full profile
Ticagrelor
Platelet aggregation inhibitors excl. heparin
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
8.2M
people
25
abandoned
Tigecycline — full profile
Tigecycline
Tetracyclines
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
4
abandoned
Timolol — full profile
Timolol
Beta blocking agents, non-selective
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
18.4M
people
0
abandoned
Timolol Maleate — full profile
Timolol Maleate
Beta blocking agents, non-selective
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
18.4M
people
55
abandoned
Tinidazole — full profile
Tinidazole
Imidazole derivatives
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
27
abandoned
Tioconazole — full profile
Tioconazole
Imidazole and triazole derivatives
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
3.4M
people
2
abandoned
Tiopronin — full profile
Tiopronin
Other urologicals
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Tiotropium Bromide — full profile
Tiotropium Bromide
Anticholinergics
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
16.4M
people
0
abandoned
Tipiracil Hydrochloride; Trifluridine — full profile
Tipiracil Hydrochloride; Trifluridine
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Tirofiban Hydrochloride — full profile
Tirofiban Hydrochloride
Platelet aggregation inhibitors excl. heparin
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
5.6M
people
19
abandoned
Tizanidine Hydrochloride — full profile
Tizanidine Hydrochloride
Other centrally acting agents
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
19.4M
people
17
abandoned
Tobramycin — full profile
Tobramycin
Other aminoglycosides
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
32
abandoned
Tobramycin Sulfate — full profile
Tobramycin Sulfate
Other aminoglycosides
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
70
abandoned
Tolmetin Sodium — full profile
Tolmetin Sodium
Acetic acid derivatives and related substances
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
15.4M
people
0
abandoned
Tolterodine Tartrate — full profile
Tolterodine Tartrate
Drugs for urinary frequency and incontinence
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
18.2M
people
63
abandoned
Tolvaptan — full profile
Tolvaptan
Vasopressin antagonists
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
8.1M
people
13
abandoned
Topiramate — full profile
Topiramate
Centrally acting antiobesity products
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
16.5M
people
32
abandoned
Topotecan Hydrochloride — full profile
Topotecan Hydrochloride
Topoisomerase 1 (TOP1) inhibitors
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
51
abandoned
Toremifene Citrate — full profile
Toremifene Citrate
Anti-estrogens
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
9
abandoned
Torsemide — full profile
Torsemide
Sulfonamides, plain
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
9.1M
people
1
abandoned
Tramadol Hydrochloride — full profile
Tramadol Hydrochloride
Other opioids
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
21.6M
people
63
abandoned

All of these medicines carry manufacturers, routes and patent status, and each one has its own page with the full profile — composition, reach, binding targets, candidate new uses and trial status. 735 also carry measured binding targets, and 110 have had possible new uses checked against trial records. The remainder are unanalysed, not ruled out. Brand-name medicines with no generic are searchable but kept out of the list, since a company still owns them. Possible uses are drawn from published target–condition links and counted only where the drug engages that target at a dose people already tolerate. Direction checks read variant-consequence annotations, which mislabel some gain-of-function variants, so treat them as a screen rather than a verdict. Nothing here is medical advice.