The Orphaned Pharmacopoeia LogoOff-patent medicine · new uses

Medicines we already have,
for diseases nobody
tried them on

Every generic approved in the United States, with what it is made of, where in the body it reaches, what else its biology points at, and whether anyone has run the trial.

1,208
Generic medicines
off-patent, human safety already established
550
New uses checked
one medicine paired with one condition it is not approved for
312
Never tested in people
no registered trial anywhere for that pairing
28
Stopped after Phase 2
safety and dosing already established, then abandoned
WHAT IT COULD TREAT
WHAT IT'S BUILT FROM
HOW FAR ANYONE HAS TAKEN IT
Showing 10811120 of 1,208 generic medicines
Sodium Nitroprusside — full profile
Sodium Nitroprusside
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Sodium Oxybate — full profile
Sodium Oxybate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Sodium Phenylbutyrate — full profile
Sodium Phenylbutyrate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Sodium Phosphate, Dibasic, Anhydrous; Sodium Phosphate, Monobasic, Monohydrate — full profile
Sodium Phosphate, Dibasic, Anhydrous; Sodium Phosphate, Monobasic, Monohydrate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Sodium Phosphate, Dibasic, Heptahydrate; Sodium Phosphate, Monobasic, Monohydrate — full profile
Sodium Phosphate, Dibasic, Heptahydrate; Sodium Phosphate, Monobasic, Monohydrate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Sodium Polystyrene Sulfonate — full profile
Sodium Polystyrene Sulfonate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Sodium Tetradecyl Sulfate — full profile
Sodium Tetradecyl Sulfate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
9
abandoned
Sodium Zirconium Cyclosilicate — full profile
Sodium Zirconium Cyclosilicate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Solifenacin Succinate — full profile
Solifenacin Succinate
Drugs for urinary frequency and incontinence
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
18.2M
people
55
abandoned
Spironolactone — full profile
Spironolactone
Aldosterone antagonists
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
12.9M
people
17
abandoned
Sterile Water For Injection — full profile
Sterile Water For Injection
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Sterile Water For Irrigation — full profile
Sterile Water For Irrigation
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Streptomycin Sulfate — full profile
Streptomycin Sulfate
Antibiotics
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
10
abandoned
Strontium Chloride Sr-89 — full profile
Strontium Chloride Sr-89
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Succinylcholine Chloride — full profile
Succinylcholine Chloride
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Sucralfate — full profile
Sucralfate
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Sufentanil Citrate — full profile
Sufentanil Citrate
Opioid anesthetics
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
21.6M
people
0
abandoned
Sugammadex Sodium — full profile
Sugammadex Sodium
Antidotes
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
32
abandoned
Sulfadiazine — full profile
Sulfadiazine
Combinations of sulfonamides and trimethoprim, incl. derivatives
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
29.0M
people
0
abandoned
Sulfamethoxazole; Trimethoprim — full profile
Sulfamethoxazole; Trimethoprim
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Sulfasalazine — full profile
Sulfasalazine
Aminosalicylic acid and similar agents
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
42
abandoned
Sulindac — full profile
Sulindac
Acetic acid derivatives and related substances
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
19
abandoned
Sumatriptan — full profile
Sumatriptan
Selective serotonin (5HT1) agonists
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
5.2M
people
0
abandoned
Sumatriptan Succinate — full profile
Sumatriptan Succinate
Selective serotonin (5HT1) agonists
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
5.2M
people
17
abandoned
Tacrolimus — full profile
Tacrolimus
Agents for dermatitis, excluding corticosteroids
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
18.9M
people
40
abandoned
Tadalafil — full profile
Tadalafil
Testosterone-5-alpha reductase inhibitors
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
12.1M
people
17
abandoned
Tafluprost — full profile
Tafluprost
Prostaglandin analogues
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Tamoxifen Citrate — full profile
Tamoxifen Citrate
Anti-estrogens
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
17.1M
people
34
abandoned
Tasimelteon — full profile
Tasimelteon
Melatonin receptor agonists
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
9.8M
people
0
abandoned
Tavaborole — full profile
Tavaborole
Other antifungals for topical use
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
16.5M
people
27
abandoned
Tazarotene — full profile
Tazarotene
Other antipsoriatics for topical use
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
15.9M
people
0
abandoned
Technetium Tc-99M Mebrofenin Kit — full profile
Technetium Tc-99M Mebrofenin Kit
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Technetium Tc-99M Mertiatide Kit — full profile
Technetium Tc-99M Mertiatide Kit
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Technetium Tc-99M Pentetate Kit — full profile
Technetium Tc-99M Pentetate Kit
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Technetium Tc-99M Sestamibi Kit — full profile
Technetium Tc-99M Sestamibi Kit
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Technetium Tc-99M Sulfur Colloid Kit — full profile
Technetium Tc-99M Sulfur Colloid Kit
Class not recorded
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned
Telmisartan — full profile
Telmisartan
Angiotensin II receptor blockers (ARBs), plain
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
13.6M
people
63
abandoned
Temazepam — full profile
Temazepam
Benzodiazepine derivatives
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
44
abandoned
Temozolomide — full profile
Temozolomide
Other alkylating agents
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
70
abandoned
Temsirolimus — full profile
Temsirolimus
Mammalian target of rapamycin (mTOR) kinase inhibitors
no target data published
Where the molecule reaches: circulation · brain · gut · skin · urinary tract
new uses
people
0
abandoned

All of these medicines carry manufacturers, routes and patent status, and each one has its own page with the full profile — composition, reach, binding targets, candidate new uses and trial status. 735 also carry measured binding targets, and 110 have had possible new uses checked against trial records. The remainder are unanalysed, not ruled out. Brand-name medicines with no generic are searchable but kept out of the list, since a company still owns them. Possible uses are drawn from published target–condition links and counted only where the drug engages that target at a dose people already tolerate. Direction checks read variant-consequence annotations, which mislabel some gain-of-function variants, so treat them as a screen rather than a verdict. Nothing here is medical advice.